Lobular Carcinoma In Situ

• Usually incidental finding at biopsy
• Younger premenopausal women
• 1% risk of breast cancer per year
• The future cancer can appear in either breast
• If surgery is to be considered, the procedure of choice is bilateral mastectomy
• Tamoxifen can reduce future risk of breast cancer by 50%

Increased probability of developing a carcinoma of the breast

• This can happen in 20-30 years after diagnosis of LCIS (Lobular carcinoma in situ)
• 1% risk increase of breast cancer per year in someone diagnosed with LCIS
• No role for sentinel lymph node biopsy.
• Treatment for Lobular Carcinoma In Situ (LCIS)
• Close observation
• Consider repeat mammogram in 6 months.
• Informed of increased risk of breast cancer
• No role for re-excision, SLN or irradiation.
• Tamoxifen should be considered with a nearly 50% reduction in cancer formation in women with LCIS
• For patients who insist on a surgical operation – a bilateral total mastectomy would be the procedure of choice because the risk of breast cancer is equal on both sides.